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Press Release

Pozen to Present at Wells Fargo Securities Health Care Conference

CHAPEL HILL, N.C.--(BUSINESS WIRE)--Feb. 25, 2005--POZEN, Inc. (NASDAQ: POZN) announced today that John R. Plachetka, Pharm.D., the company's chairman, president and chief executive officer, will be speaking to investors at the Wells Fargo Securities Health Care Conference on Tuesday, March 1, 2005 at 11:15 a.m. Eastern Time in New York City. Dr. Plachetka's presentation will be webcast and archived on POZEN's home page at www.pozen.com.

POZEN is a pharmaceutical company committed to developing therapeutic advancements for diseases with unmet medical needs where it can improve efficacy, safety, and/or patient convenience. Since its inception, POZEN has focused its efforts primarily on the development of pharmaceutical products for the treatment of migraine. POZEN is also exploring the development of product candidates in other pain-related therapeutic areas. POZEN has development and commercial alliances with GlaxoSmithKline, Xcel Pharmaceuticals, and Nycomed. The company's common stock is traded on The Nasdaq Stock Market under the symbol "POZN". For detailed company information, including copies of this and other press releases, see POZEN's website: www.pozen.com.

CONTACT:
POZEN, Inc.
Bill Hodges
Chief Financial Officer
919-913-1030
Fran Barsky
Director, Investor Relations
919-913-1044

SOURCE: POZEN, Inc.