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Press Release

Pozen Announces April 29 Webcast of First Quarter Results

CHAPEL HILL, N.C.--(BUSINESS WIRE)--April 22, 2004--POZEN Inc. (NASDAQ: POZN), announced today that it will release first quarter results on April 29, 2004, before the market opens.

The announcement will be followed by a live webcast at 11:00 a.m. Eastern Time of a discussion by POZEN management of the earnings and business results. The webcast can be accessed on POZEN's website at www.pozen.com and will be archived and available for replay. The first quarter earnings release can be accessed in the News section of POZEN's website.

POZEN is a pharmaceutical company developing therapeutic advancements in a cost effective manner. Product development efforts are focused on diseases with unmet medical needs where POZEN can improve efficacy, safety, and/or patient convenience. Since its inception, POZEN has developed the largest and most advanced product pipeline in the field of migraine. POZEN has development and commercial alliances with GlaxoSmithKline, Xcel Pharmaceuticals, and Nycomed. The company's common stock is traded on The Nasdaq Stock Market under the symbol "POZN". For detailed company information, including copies of this and other press releases, see POZEN's website: www.pozen.com.

Lisa Barthelemy, 919-913-1044
John Barnhardt, 919-913-1030