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Press Release

POZEN Sponsors Habitat for Humanity Home in Hillsborough, North Carolina

CHAPEL HILL, N.C.--(BUSINESS WIRE)--Sept. 8, 2008--POZEN Inc. (NASDAQ: POZN), announced today that the company, together with a matching contribution from the Plachetka Family Fund of Triangle Community Foundation, have donated a total of $70,000 to Habitat for Humanity of Orange County (HHOC) (www.orangehabitat.org) for the construction of a Habitat home in Hillsborough, North Carolina. The Habitat team, consisting of POZEN employees who are volunteering their time, will raise the walls on the Habitat home with a groundbreaking ceremony at 8:30 a.m. on Saturday, September 13, 2008.

"The late Joe Ruvane, former chief executive officer of Glaxo and one of my co-founders of POZEN, taught me to give back to the community and to be a good corporate citizen," said Dr. John R. Plachetka, POZEN's chairman, president and chief executive officer. "In that spirit, we are pleased to work with HHOC on this project."

About POZEN

POZEN is a pharmaceutical company committed to developing therapeutic advancements for diseases with unmet medical needs where it can improve efficacy, safety, and/or patient convenience. POZEN's efforts are focused primarily on the development of pharmaceutical products for the treatment of acute and chronic pain and other pain-related conditions. POZEN has development and commercialization alliances with GlaxoSmithKline for Treximet(TM), which was approved by the United States Food and Drug Administration for the acute treatment of migraine attacks, with or without aura, in adults, and with AstraZeneca for proprietary fixed dose combinations of naproxen with the proton pump inhibitor esomeprazole magnesium in a single tablet for conditions such as osteoarthritis and rheumatoid arthritis in patients who are at risk for developing NSAID-associated gastric ulcers. The company's common stock is traded on The Nasdaq Stock Market under the symbol "POZN". For detailed company information, including copies of this and other press releases, see POZEN's website: www.pozen.com.

About Habitat

Habitat for Humanity of Orange County (HHOC) is a not-for-profit ecumenical housing ministry whose primary mission is to change lives by bringing together God's people and resources to help families in need build and own quality affordable homes. Since 1984, HHOC, an affiliate of Habitat for Humanity International, has built over 160 homes with thousands of local volunteers. For more information about HHOC, visit www.orangehabitat.org.

Directions to Hillsborough: I-40 West to Exit 261. Turn Right at end of exit onto Old Chapel Hill/Hillsborough Road. Name changes to Churton Street North to Hwy 70. Left on Hwy 70/Cornelius Road. Right on Rainey Street. Pass Fairview Park. Left on Dixie Drive. Right on Harper Street. Right on Tulip Tree Road. Left onto Locust Road. Look for event signs.

CONTACT: POZEN Inc.
Bill Hodges
Chief Financial Officer
919-913-1030
or
Fran Barsky
Director, Investor Relations
919-913-1044

SOURCE: POZEN Inc.